Subject: TS

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1.1 Overview of microbial community composition

Figure 1 is an interactive figure showing the microbial community composition in each collected sample. Here, each color and shade corresponds to a different genus. For reference, domestic dogs (Canis familiaris) and gray wolves (Canis lupus) are different species that belong to the same genus (Canis).

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Figure 1: Microbial community composition of collected saliva, stool, and CapScan samples. CapScan samples are ordered from proximal to distal intestine (i.e., increasing distance from mouth). Taxonomic composition is reported at the genus rank. Genera present at <1% relative abundance across all samples are reported as “Other genera”. Note: Blue = Firmicutes; Yellow = Actinomycetes; Green = Bacteroidetes; Red = Proteobacteria; Purple = all other phyla. Shades of the same color (except purple) correspond to different genera from the same phylum.



1.2 High-resolution snapshot of community composition

Figure 2 is an interactive figure showing the microbial community composition at higher taxononomic resolution. Here, each row corresponds to a unique microbe.

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Figure 2: Heat map showing relative abundance of microbes in each sample (N = 266 total identified). Each row corresponds to a unique microbe and each column corresponds to an individual sample. Note the relative abundance colorscale is in log units.



1.3 Notable microbes detected



1.4 References

Kanki, M., Yoda, T., Tsukamoto, T., and Shibata, T. (2002) Klebsiella pneumoniae produces no histamine: Raoultella planticola and Raoultella omithinolytica strains are histamine producers. Appl Environ Microbiol 68: 3462–3466.

Kaur, C.P., Vadivelu, J., and Chandramathi, S. (2018) Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases. J Dig Dis 19: 262–271.